Beyond Achondroplasia

Growing together with Clara

January 26, 2017
by inesp.alves
1 Comment

Accelerating bone formation during limb lengthening

Currently, we stand in a great moment of drug development for achondroplasia with one drug in clinical trial, that just started phase 3 (Vosoritide) and another one, the TA-46, that maybe will start clinical trial phase 1 soon. And there … Continue reading

March 20, 2016
by inesp.alves

Hearing disturbance in achondroplasia

“Achondroplasia has a variety of head and neck manifestations. The otolaryngologic complications include respiratory manifestations as a result of upper airway obstruction and frequent otitis media which may be accompanied by hearing loss and delayed speech”. Bilateral Ossiculoplasty in 1 Case … Continue reading

June 18, 2015
by inesp.alves

Breaking news – BMN-111 Phase 2 proof-of-concept report

Vosoritide is the name we will know from now on. It’s the generic name of BMN-111 Report from the BioMarin announced positive results of a Phase 2 proof-of-concept and dose finding study of BMN 111 (vosoritide), an analog of … Continue reading

June 10, 2015
by inesp.alves

Increased bone turnover and possible accelerated fracture healing in a murine model with an increased circulating C-type natriuretic peptide – Nakao 2015

Bone turnover – total volume of bone that is resorbed and formed over a period of time, usually expressed as percent/year. It can be estimated by measuring relevant bone biomarkers [1]. Bone remodelling – It’s a dynamic physiological event and … Continue reading

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